A Bioconductor package for investigation of network heterogeneity from high-dimensional data

Simplifying the process greatly, signalling proteins known as kinases can be unphosphorylated (inactive) or phosphorylated (active). Cell signalling uses the phosphorylation machinery to pass messages from the exterior of the cell to the interior where they will be acted upon. This message passing is achieved via a relay of kinases and other proteins (the signalling pathway), which can be thought of as a network.